Meshima Mushroom Tincture

Mesima is rich in compounds known as Beta D-glucans, compounds that are known as "biological response modifiers". They bind to the surface of innate immune cells which allows the cells to have better co-ordination in their attack. This reduces the tendency toward auto-immune reactions and hyper-inflammatory activity when the body is under attack.

Phellinus linteus was discovered a thousand years ago in China. In 1968 it was taken for clinical studies by Japanese National Cancer Center Research Institute, the results amazed the scientists that Meshima had the highest anti-abnormal cells rate at 96.7% among all tested mushrooms. This discovery caused the boom of Meshima research and development in Japan and South Korea. In 1997, the Korean government officially recognized it as a treatment against critical diseases.

Meshima grows on mulberry trees that have potential lifetimes of more than 100 years. Perfect growth conditions for a minimum of 30 – 40 years is essential for the fruit body to gain its valuable medicinal applications. This is why natural Meshima is exceedingly rare.

Meshima as an immunotherapy for critical diseases.

Generally there are three methods in treating cancer: surgical therapy, radiation therapy and chemotherapy (anticancer drugs).
These 3 types of therapies, in addition to dealing with cancer cells, may destroy normal cells as well, resulting in declined immune system of cancer patients and bring serious side effects.
Immunotherapy has risen recently as the fourth choice of cancer therapy (or as complementary therapy) through enhance one's body own immune system to fight tumor cells.

Meshima is internationally accepted as the best anti-abnormal cells medicinal mushroom, it can significantly improve patients' immune system. When used together with anti-cancer drugs, they can work synergistically by significantly enhancing the anti-abnormal cells effect and relieve the side effects caused by drugs, such as loss of appetite, vomiting and hair loss.

Additionally, the Mesima Mushroom contains potent antioxidants that help to prevent and repair DNA damage in the body thus preventing disease. Korean researchers have recently identified hispidin, a resveratrol-like compound found in Mesima that is believed to be the key antioxidant molecule, possessing an antioxidant efficacy equivalent to vitamin C.

Women’s Health
Certain cases of infertility can be associated with elevated cytokine and NK (natural killer cells) levels. Consumption of Mesima Mushroom has been shown to lower these levels, thus increasing the chances of a successful conception.
Mesima Mushroom is also well known to help control excessive monthly bleeding during periods. Such are its blood staunching abilities that it is currently under investigation to determine if it can control haemophilia.
Finally, there are studies that have researched the contribution of this mushroom to breast health. Many of Mesima’s immunologic actions show specific promise for maintaining healthy breast cells. Its anti-inflammatory properties coupled with the rich polysaccharide content also help to protect and preserve the delicate breast tissue.

Allergies
Numerous studies have proven that the polysaccharides of Mesima are highly effective in treating immune imbalances and allergic reactions. Specifically, the active components in the mushroom are capable of suppressing Th2 cytokines and conversely inducing secretion of Th1 cytokines - immune cells that promote a more balanced immune system which is more capable of fighting off allergies.

Furthermore, extracts of this mushroom have been reported to display the ability to suppress the release of histamine in the body, even after the introduction of known allergic stimuli. This makes Mesima a suitable treatment for patients suffering from various skin ailments such as atopic dermatitis or asthma caused by allergies.

Folklore and History
The Mesima Mushroom has been revered for thousands of years in China and Japan. Emperors of the great Chinese Dynasties and Japanese royalty drank tea and concoctions made from Phellinus linteus for vitality and long life.  In ancient Chinese History, the first emperor of China, Emperor Qin Shi Huang, in 220 BCE sent 3000 boys and girls to Japan’s outlying islands to search for this funghi, believed to be the elixir of eternal youth.
Shen Nong's Herbal Classic (considered today as the oldest book on oriental herbal medicine), classifies Mesima as number one in the superior medicines category. Exalted since ancient times for its absence of side effects, Mesima has many applications, especially for perceived youthfulness and longevity.
With a distinct bitter taste, this mushroom is not at all pleasant to eat, however in Korea it is commonly consumed in the form of a medicinal tea.

Traditional Use
The Mesima Mushroom is an orange coloured, hoof shaped mushroom that grows on mulberry trees. This potent mushroom has been used medicinally for thousands of years in Chinese, Japanese and Korean healing systems.
Traditional uses range from healing the digestive tract to staunching heavy bleeding – especially in women who experience menorrhagia, abnormally heavy bleeding during the menstrual cycle. Interestingly, its literal translation is “Women’s Island" and it is becoming increasingly known in the Western world for its remarkable women’s health benefits.
Mesima has been used for centuries as a general tonic to promote overall health, well-being and longevity in Asian cultures.
 

Constituents
Mesima Mushroom constituents include: Beta D-glucan, lectin, polysaccharide, protocatechuic acid, protocatechualdehyde, caffeic acid, ellagicacid, hispidin, davallialactone, hypholomine B, interfungins A (an inhibitor of protein glycation), and inoscavin.

-Polysaccharide (1-3)-beta glucan: The concentration of (1-3)-beta glucan is twice than that of Agaricus Blazei Murill; it stimulates immune cells11,12,16 like Natural Killer cells, macrophages, dendritic cells and leukocytes. It prevents and inhibits the growth of abnormal cells, at the same time relieving the side effects of anti-cancer chemo drugs.

-Triterpenoids: Enhance detoxification in liver and act against viral infection2,5. It also helps lowering circulatory pressure by inhibiting the activity of the enzyme ACE2.

-Ergosterol: It is a precursor of vitaman D. Vitamin D helps absorption of calcium which in turn can prevent the development of osteoporosis.

Precautions
Not recommended in pregnancy. 

 

 

1Gi-Young Kim, Jae-Yoon Lee, Jeong-Ok Lee, Chung-Ho Ryu, Byung Tae Choi, Yong-Ki Jeong, Ki-Wan Lee, Sang-Chul Jeong, Yung Hyun Choi. 2006. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus.

 https://pubmed.ncbi.nlm.nih.gov/16717425/

 

2D Sliva,  A Jedinak, J Kawasaki, K Harvey, V Slivova. 2008. Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361714/

3Guang Hai Yan, Yun Ho Choi. 2014. Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022778/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7036851/

 

Ikekawa et al. Jpn J Cancer Res. 1968;59:155-157

A medicinal mushroom: Phellinus linteus. Zhu T, Kim S.H, Chen C.Y. Curr Med Chem. 2008;15(13):1330-5.

Shibata Y, Kurita S, Okugi H, Yamanaka H. Urol Int. 2004;73(2):188-90.

Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. Nam S.W, Han J.Y, Kim J.I, Park S.H, Cho S.H, Han N.I, Yang J.M, Kim J.K, Choi S.W, Lee Y.S, Chung K.W, Sun H.S. J Gastroenterol Hepatol. 2005;20(3):488-92.

A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases. Kojima H, Tanigawa N, Kariya S, Komemushi A, Shomura Y, Sawada S, Arai E, Yokota Y. Radiat Med. 2006;24(2):139-42.

Guo J, Zhu T, Collins L, Xiao Z.X, Kim S.H, Chen C.Y. Mol Carcinog. 2007;46(2):144-54.

Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer. Collins L, Zhu T, Guo J, Xiao Z.J, Chen C.Y. Br J Cancer. 2006;95(3):282-8.

Zhu T, Guo J, Collins L, Kelly J, Xiao Z.J, Kim S.H, Chen C.Y. Br J Cancer. 2007;96(4):583-90.

Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V. Br J Cancer. 2008;98(8):1348-56.

Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Konno S, Alt Med Rev. 2007;12(1):63-68.

Han S.B, Lee C.W, Kang J.S, Yoon Y.D, Lee K.H, Lee K, Park S.K, Kim H.M. Int Immunopharmacol. 2006;6(4):697-702.

Han B, Lee C.W, Jeon Y.J, Hong N.D, Yoo I.D, Yang K.H, Kim H.M. Immunopharmacology. 1999;41:157-164.

Oral administration of proteoglycan isolated from Phellinus linteus in the prevention and treatment of collagen-induced arthritis in mice. Kim G.Y, Kim S.H, Hwang S.Y, Kim H.Y, Park Y.M, Park S.K, Lee M.K, Lee S.H, Lee T.H, Lee J.D. Biol Pharm Bull. 2003;26(6):823-31.

Antiarthritic activity of a Polysaccharide-protein complex isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae) in Freund's complete adjuvant−induced arthritic rats. Meera C.R, Smina T.P, Nitha B, Mathew J, Janardhanan K.K. Int J Med Mushr. 2009;11(1):21-28.

Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Kim G.Y, Roh S.I, Park S.K, Ahn S.C, Oh Y.H, Lee J.D, Park Y.M. Biol Pharm Bull. 2003;26(10):1418-23.

Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Kim H.M, Han S.B, Oh G.T, Kim Y.H, Hong D.H, Hong N.D, Yoo I.D. Int J Immunopharmac. 1996;18(5):295-303